Nurse Practitioner Salary in South Carolina: $125,621 (2026)
Quick Answer:Across South Carolina's 26 metropolitan areas, the average median nurse practitioner pay sits at $125,621/year heading into 2026 — a figure projected from 2025 BLS OEWS wage data for SOC 29-1171. Because South Carolina sits at BEA RPP 91.5 (8% below the U.S. baseline), that statewide median translates to roughly $137,291 in nationally-comparable purchasing power. Highest-paying metros: North Charleston ($130,504), Charleston ($127,780), Greer ($122,157).
In 2026, nurse practitioners in South Carolina are projected to earn an average median salary of $125,621, which is 8.2% lower than the national median of $136,864. The highest salaries can be found in North Charleston, where practitioners may earn $135,006, while Clemson residents can expect the lowest average salary of $114,507. This salary gap of $20,499 between North Charleston and Clemson can be attributed to factors such as local demand for healthcare services, cost of living variations, and city-specific healthcare market dynamics. South Carolina’s scope of practice laws allow nurse practitioners to perform many of the same services as physicians, which has driven greater demand, particularly in rural areas facing physician shortages. The state has a robust growth rate of 3.45%, reflecting an increasing need for healthcare professionals. With a total of 4,361 nurse practitioners employed across 26 metro areas, job opportunities appear to be solid. The top five projected paying cities include Charleston at $132,188, Greer at $126,371, Anderson at $126,243, and Mount Pleasant at $126,171. These figures signify a positive outlook for current and prospective nurse practitioners in South Carolina.
South Carolina Nurse Practitioner Salary Range
Overall salary range in South Carolina: $84,736 (lowest entry-level) to $177,329 (highest top earner)
South Carolina vs National Average
South Carolina nurse practitioners earn 8.21% less than the national median ($-11,243/year difference).
South Carolina Nurse Practitioner Salary Distribution (2026)
Nurse Practitioner salaries in South Carolina range from $98,267 (entry-level, 10th percentile) to $155,859 (top earners, 90th percentile), with a median of $125,621. The South Carolina median is $11,243 below the US national median of $136,864. The average hourly rate is $60.40/hr. Approximately 4,361 nurse practitioners are employed across 26 cities.
2019 BLS Actual
$97,977
2025 BLS Actual
$121,432
2026 Current Est.
$125,621
2019–2027 Growth
+32.6%
Salary Trajectory for Nurse Practitioners in South Carolina (2019–2027)
2019–2025: actual BLS OEWS data for this metro area. 2026+: CAGR 3.45% projection.
| Year | Annual Salary | Status |
|---|---|---|
| 2019 | $97,977 | Actual |
| 2020 | $99,299 | Actual |
| 2021 | $100,838 | Actual |
| 2022 | $103,827 | Actual |
| 2023 | $113,307 | Actual |
| 2024 | $115,732 | Actual |
| 2025 | $121,432 | Actual |
| 2026(current) | $125,621 | Estimated |
| 2027 | $129,955 | Projected |
Based on 7 years of BLS OEWS data for the South Carolina metropolitan area, the median nurse practitioner salary grew 23.9% from $97,977 (2019) to $121,432 (2025). At a 3.45% compound annual growth rate, salaries are projected to reach $129,955 by 2027 — a total increase of $31,978 (32.64%) from 2019.
Note: Historical values (2019–2025) are actual BLS OEWS figures for the South Carolina metropolitan area, sourced from annual Occupational Employment and Wage Statistics surveys. 2026–2026 figures are current estimates, and 2027 values are projections, calculated using a 3.45% CAGR derived from 7-year BLS historical data. Actual salaries may vary based on employer, experience, certifications, and local market conditions.
Top 5 Highest Paying Cities in South Carolina
Lowest Paying Cities in South Carolina
Best Value Cities for Nurse Practitioners in South Carolina
When adjusted for local cost of living, these South Carolina cities offer the most purchasing power for nurse practitioners.
| City | Nominal Salary | CoL Index | Adjusted Salary |
|---|---|---|---|
| North Charleston | $135,006 | 91.5 | $147,548 |
| Florence | $126,137 | 86.774 | $145,363 |
| Greer | $126,371 | 91.5 | $138,110 |
| Anderson | $126,243 | 91.5 | $137,970 |
| Mount Pleasant | $126,171 | 91.5 | $137,892 |
Adjusted salary = nominal salary × (100 / CoL index). CoL index: 100 = national average. Lower index = lower cost of living.
Salary by Experience Level in South Carolina
| Experience Level | Estimated Annual |
|---|---|
| Entry Level (0-2 years) | $98,267 |
| Mid Career (3-7 years) | $125,621 |
| Experienced (7+ years) | $155,859 |
Estimates based on BLS percentile data averaged across South Carolina metro areas. Individual pay varies by employer, certifications, and specialization.
All 26 Cities in South Carolina
| # | City | Median Salary |
|---|---|---|
| 1 | North Charleston | $135,006 |
| 2 | Charleston | $132,188 |
| 3 | Greer | $126,371 |
| 4 | Anderson | $126,243 |
| 5 | Mount Pleasant | $126,171 |
| 6 | Florence | $126,137 |
| 7 | Myrtle Beach | $125,578 |
| 8 | Spartanburg | $125,299 |
| 9 | Rock Hill | $123,847 |
| 10 | Greenville | $123,395 |
| 11 | Aiken | $123,304 |
| 12 | Conway | $123,263 |
| 13 | Hilton Head Island | $123,240 |
| 14 | Hanahan | $123,130 |
| 15 | Columbia | $122,557 |
| 16 | Mauldin | $122,406 |
| 17 | Summerville | $121,749 |
| 18 | Bluffton | $120,899 |
| 19 | Simpsonville | $119,742 |
| 20 | Fort Mill | $119,686 |
| 21 | Goose Creek | $119,405 |
| 22 | Lexington | $117,452 |
| 23 | Sumter | $115,947 |
| 24 | Easley | $115,357 |
| 25 | Tega Cay | $114,721 |
| 26 | Clemson | $114,507 |
More South Carolina Salary Data
Hourly Rates
Explore nurse practitioner hourly pay in South Carolina cities.
Senior / Experienced
Top earner salaries for experienced nurse practitioners.
Explore More Nurse Practitioner Salary Data
Frequently Asked Questions
How much do nurse practitioners make in South Carolina in 2026?
What is the highest paying city for nurse practitioners in South Carolina?
How does South Carolina nurse practitioner pay compare to the national average?
What is the entry-level nurse practitioner salary in South Carolina?
How many nurse practitioners are employed in South Carolina?
Which South Carolina city offers the best value for nurse practitioners?
Written by Maria Gonzalez, MSN, NP-C
Career Analyst
Maria has 10 years of experience in adult healthcare. She works in a community health clinic. Her specialty is chronic disease management.
Methodology & Data Source
Statewide salary figures on this page are 2026 projections based on the Bureau of Labor Statistics Occupational Employment and Wage Statistics (OEWS) survey, May 2026 release. A 3.45% compound annual growth rate (CAGR), derived from 6-year national BLS wage trends, was applied to each metro area's reported salary to estimate current 2026 nurse practitioner compensation across South Carolina. State averages are employment-weighted across 26 metro areas — larger metro areas with more nurse practitionerscontribute proportionally more to the average, producing figures that better reflect typical compensation. Individual pay varies by city, employer, certifications, and experience.
Data Sources & Methodology
Source: BLS, OEWS, 7-year dataset (–). Per-city data from annual BLS metropolitan area surveys.
2026 figures are projected from 2025 BLS data using a compound annual growth rate (CAGR) of 3.45%, derived from historical BLS wage trends for nurse practitioners (SOC 29-1171).
Compiled and verified by Maria Gonzalez, MSN, NP-C, a licensed nurse practitioner with 10+ years of clinical experience. · View source data at BLS.gov