Springfield vs St. Louis: Nurse Practitioner Salary (2026)
Compare nurse practitioner salaries between Springfield, MO and St. Louis, MO. All figures are 2026 estimates projected from BLS 2025 data.
Side-by-Side Comparison
| Metric | Springfield, MO | St. Louis, MO |
|---|---|---|
| Median Salary | $129,964 | $136,120▲ |
| Hourly Rate | $62.48 | $65.44▲ |
| Entry Level (P10) | $98,578 | $112,078▲ |
| 25th Percentile | $112,336 | $131,857▲ |
| 75th Percentile | $135,364 | $159,830▲ |
| Top Earner (P90) | $158,237 | $169,948▲ |
| Total Employed | 660 | 3,430▲ |
Verdict
St. Louis, MO offers better overall compensation for nurse practitioners, winning 4 out of 4 metrics compared to Springfield.
The salary gap between Springfield and St. Louis is $6,156 (4.74%). St. Louis's median is -0.54% compared to the US national median of $136,864.
Salary Range Comparison
The full salary range (10th to 90th percentile) in Springfield spans $59,659,St. Louis spans $57,870. Springfield has a wider pay range, meaning more potential for high earners but also more variation.
Cost-of-Living Adjusted Comparison
After cost-of-living adjustment, Springfield ($146,711 effective) pays 2.49% more than St. Louis ($143,152 effective).
Cost-of-living adjustment: salary × (100 / CoL index). Index of 100 = national average.
Which City Is Right for You?
Choose Springfield if…
- ✓Better purchasing power (CoL-adjusted: $146,711)
- ✓You prefer the Missouri area and lifestyle
Choose St. Louis if…
- ✓Higher median salary ($136,120/year)
- ✓Better top-earner potential ($169,948)
- ✓Larger job market (3,430 employed)
- ✓You prefer the Missouri area and lifestyle
Historical Salary Growth Comparison
Based on BLS OEWS metropolitan area data, nurse practitioner salaries in Springfield grew 37.1% from 2019 to 2025, compared to 31.1% growth in St. Louis over the same period.
Springfield, MO
$91,660 (2019) → $125,630 (2025)
St. Louis, MO
$100,340 (2019) → $131,580 (2025)
View Full Salary Data
Springfield, MO
St. Louis, MO
Frequently Asked Questions
Which city pays nurse practitioners more: Springfield or St. Louis?
What is the hourly rate difference between Springfield and St. Louis?
Should I relocate from Springfield to St. Louis as a nurse practitioner?
What do entry-level nurse practitioners earn in Springfield vs St. Louis?
Related Comparisons
Written by Maria Gonzalez, MSN, NP-C
Career Analyst
Maria has 10 years of experience in adult healthcare. She works in a community health clinic. Her specialty is chronic disease management.
Methodology & Data Source
All salary figures are 2026 projections based on BLS OEWS May 2025 data. A 3.45% CAGR (derived from 6-year national BLS trends) was applied to estimate current compensation. Cost-of-living adjustments use BEA Regional Price Parity data. Actual salaries vary by employer, certifications, and experience.
Data Sources & Methodology
Source: BLS, OEWS , released .
Compiled and verified by Maria Gonzalez, MSN, NP-C, a licensed nurse practitioner with 10+ years of clinical experience. · View source data at BLS.gov